And no, I don't mean applying blockchain to everything, or internet money that just goes "up and to the right".
I mean the new applications of distributed systems research and cryptographic primitives that allow for highly composable, highly trustworthy, permissionless, autonomous machines.
MakerDAO, Arweave, the whole field of open finance (aka "DeFi"), and so many others collectively are very likely to change the fundamental assumptions we make when using software.
Here's a great talk regarding trustlessness: https://www.youtube.com/watch?v=G0rZcpfF5dU