In 2017 there were zero reported accidentally deaths [1]. Compared to 1972, one of the most dangerous years to fly, where more than 2,300 accidental deaths occurred on commercial flights.
How did we go from thousands of deaths to zero? Primarily through crashing. Then working to evaluate what went wrong and improve the design, processes, and programs around commercial aviation.
As one pilot explains [2]:
"One of the ways we’ve become so safe was to realize that our efforts were never going to be good enough."
So yes, I think technologies like autopilot will save lives. But it won't be able to do it magically, unfortunately some harm will occur because we—in all our human wisdom—just can never accurately predict all possibilities. It's the same problem most self-driving companies are facing today, and the reason promises of self-driving being here today have fallen short. The world is far, far more complex than we realize... especially when we put a computer out into it and tell it to "go forth."
https://www.reuters.com/article/us-aviation-safety/2017-safe...
https://www.usatoday.com/story/travel/columnist/cox/2018/01/...