If you made an index of penny stocks, do you think markets are efficient enough this would be basically as good as an S&P 500 fund? What if you made two indexes, one of penny stocks that pay dividends, and one of those that do not?
I've done this experiment years ago with a stock market simulator utilizing real market data, and it suggested that, no, there is not a price at which total shit is a good investment, or if there is, it's not the market price. Therefore it follows that excluding that shit from your index is potentially worthwhile.