Vancouver took their 2-lane each way (4 total) roads and dedicated the outer lane to bikes. They protected that lane from car with planters. So, it can definitely be done.
That said, IDK if it’s a resounding success. There may be measures by which it is, I’m just not aware.
For example, I found it difficult as a pedestrian and saw a few collisions and lots of near misses between bikes and pedestrians. The planters create a nice protected area which feels like it’s safe for walking and crossing. But the bikes were moving quickly and quite unyielding in their perceived right-of-way.
When we were there, there was definitely other challenges. There were terrible traffic jams - especially going into the city. It seems like a lot of traffic needs to go through the city to get somewhere else. It didn’t seem like they had adequate public transportation.