Pi Hole is a very poor substitute for uBlock origin, it doesn't block Youtube or Twitch ads for example or do anything dynamic. Plus it's full of false positives since DNS rules can be very coarse or change continuously. Not to mention the trouble you have to go to when sites break due to that coarseness or that in many cases it degrades functionality that's not immediately obvious.
uBlock origin is the king of adblocking, and suffers from none of these issues. Use anything else and you're severely compromising. I'd go as far as to say that DNS adblocking is basically a waste of resources, a gimmick, the wrong solution to a well-defined problem.