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> AAVs integrate randomly into your genome meaning that they could just by chance disrupt a gene you really need to not get cancer.

I watched the video. I am not a biologist.

I could have sworn at one point he said that it would be inserted at "known, and safe" locations. Not "random"... ?

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This is mainly true, however we are still observing random integrations at low frequency such as 0.1% to 1% [0], so if you bring a billion virus particles in, it still poses a non-negligible risk to the agent.

Thank you for your input, I'll word it more accurately.

0: https://www.ncbi.nlm.nih.gov/pubmed/29326962

Very interesting. Thanks for the clarification!

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