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Back in 2017, 60 minutes covered a group that was cured of sickle cell disease with gene therapy. How does this approach differ when they already showed success? https://www.cbsnews.com/news/could-gene-therapy-cure-sickle-...

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This study uses a different vector and targets a different gene.

The NIH study uses a modified HIV to introduce the complete gene for the defective protein.

https://www.nhlbi.nih.gov/news/2019/sickle-cell-patients-rec...

This study uses CRISPR/Cas9 to increase expression of a gene that the patients already have.

Just skimming through the article you posted, it says trials with a similar treatment resulted in one patient dying from a massive immune response and two other got cancer. Sounds like it relies on a virus to deliver the DNA, but I didn't read too carefully, so maybe CRISPR will turn out to have fewer side effects or a greater success rate. I'm pretty sure one of the up-sides to CRISPR is compared to other gene-editing techniques it's relatively cheap, which is always a plus.

The death and cancers mentioned over there were from gene therapy trials in general, not the specific study in the link.

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