I manage millions in ad spend. Targeting with individual, manual options is not efficient for most advertisers. Most performance advertisers target using lookalikes and algorithmic targeting based on optimizing for conversions.
This is 100% correct, but this list is more about knowing if some ad platform can be a good place to launch ads to a cold audience (that are more targeted for the product) - because, after a while, every single one of the 6 ad platforms allow for lookalike audiences and those will be much more profitable.