Here's why:
Let's say you have a class "column-760" for a 760px wide column. Now let's say you want to re-design the page. Not only do you have to write new styles, you have to go in and remove all the places you've written "column-760" in the actual markup. This entirely defeats the purpose of external CSS, and incorrectly couples style with content. I can't tell you how frustrating it is to work on a page that says something like:
<div class="column column-760 relative green-background"></div>
DO use content descriptive class names, DON'T use physically descriptive class names.