On the plus side, I've been running Kontakt 5 along with lots of other audio software since 10.15 beta 3 every day and most everything is working alright.
Some other observations:
• Pro Tools' QuickTime video plug-in prevents it from launching because it's a 32-bit only subprocess meant to interact with the now-defunct QuickTime framework. You can delete the plug-in from the application bundle and it will proceed and seems to be working normally.
• EastWest has a nasty crash in PLAY 6 that can be worked around temporarily by removing their internal word builder plug-in.
• Pretty much every iZotope plug-in as of September had a 32-bit non-pkg installer. The software works fine if you copy all the relevant parts from an install on another computer.
• MOTU hardware drivers for anything but the latest Pro Audio line won't work as the drivers are 32-bit at the moment (MIDI interfaces, CueMix-based audio interfaces).
But keep in mind these companies are usually pretty small, a lot of sole-proprietors out there, and their revenue comes from new products/sales not maintaining projects. So there's logistical and incentive problems in deploying fixes quickly.
I also think it's unrealistic for large applications to be 100% ready on day one. It's not like Apple has a GM ready weeks ago. Betas are known to change and nobody really knew when Catalina would ship (many people are surprised they're shipping what they have).
Just because Apple can bump out a new OS version once a year doesn't mind these app developers have the same bandwidth to keep up the chase. They have plenty of other priorities.
For the most part, it's not a technical issue at all but a cultural one : pro audio users are notoriously, almost pathologically conservative when it comes to software upgrades.
You'll find plenty of threads on forums like Gearslutz, asking for tips on how to downgrade brand new Macs to an older version of macOS that doesn't even support their hardware. Or 2019 threads asking if it's now safe to upgrade to High Sierra. They're typically 2-3 versions behind. Why ? Older is just safer, better in their worldview.
In that context, audio developers know they have customers on their side against "evil Apple that's always breaking everything for no benefit", and they get away with emails that read like Apple just unexpectedly dropped a bomb on them without notice, and it'll take them 6-12 months to get ready, like WWDC and 3-4 months of developer betas never happened.
I wonder what MacOS has that Windows doesn't(which is a lot more backward compatible) that makes audio people stick with them.
All mainstream OSes are moving to an unsustainable release cycle.
For years it has also had things like Audio Midi Setup, which lets you set up aggregate virtual audio interfaces from physical ones, dealing with latency compensation etc. Or MIDI over Bluetooth. All of that out the box. It just feels it's been designed with pro audio in mind, compared to Windows.
It's a technical issue. It's a bear to support older systems from newer machines. (it's a lot easier to support current stuff from dawn-of-time old systems! I keep an antique laptop to code on which allows me to support EVERYTHING all the way back to PPC Macs. Which I do support)
My choices of what I choose to buy (in Apple hardware) or even CAN buy are conditioned very much by this reality. I'll get stuff if there's a fighting chance I can build a working ecosystem on it. I'll be willing to do things like ditch Logic and switch to Reaper, and I'll be well within my rights to tell users 'this is what I can offer, and this is what I cannot'.
Because Apple is not automatically my ally. It can be my adversary, even when I'm doing its bidding (I was fairly early in porting my entire product line to 64-bit when few others bothered. Apple literally called me and offered to help me do this, so I told 'em I'd already done it three months before. I did NOT tell them that I continued to support PPC machines or maintained a time capsule dev machine as the only way to develop for a large range of cheaply, easily available hardware)
Users have every right to side with me against Apple when I'm an open source developer letting them do professional-quality audio work on computers costing only a few hundred dollars, and/or letting them continue to use known-good and predictable equipment, and Apple is locked in to a course of action requiring it to churn its userbase at whatever cost to the userbase.
I totally get Apple's motivation here, but it doesn't serve my customers.
As a user I only see "OS upgraded -> stuff broken". I'll blame the OS for that. All finger pointing and shoulda/coulda/woulda is not magically going to unbreak things,rolling back the upgrade will.