I run Calibre with a network share that sits on my home NAS since years w/o issues.
A corrupted database in Calibre is a non issue if all you use it for is to move books between your e-reader devices and the library. You just recreate it.
P.S.: Just for example -- the other day my MacBook's SSD filled up as Adobe InDesign was mid write on a huge document. It crashed and the file was corrupted and not recoverable. While (mid write) 'not enough space' is not the same as 'network mount went missing' or 'SSD kicked the bucket' it's close enough. And this is commercial software that has been around for 25 years.
Best of all would be in Calibre's library handling weren't so finicky, but in the absence of that, I use Calibre with a remote share and I'm just very careful about library backups, how long I leave it running, and am patient with the slowness.
I run Calibre with the library mounted from a NAS. Works fine for my ~2000 book collection. Not as speedy as local SSD, but it is ok.