Last time he was off on medical leave, they brought out a new Mac Pro that was massively more expensive than the model it replaced (to a Quadra level in the UK); they started going all MBA with the MBP, segmenting the MacBook with an aluminium MacBook and the polish on iPhone OS 3 took a nosedive into stripey-icon ugly land.
Weren't there also some awful app rejections in that period? Pretty sure there were, but either way, the impression Apple gave in those days might as well have been Apple 1992 all over again.