It's an essential thing if you want to be a successful entrepreneur -- as long as you don't confuse skepticism with cynicism. Skepticism and optimism make a powerful combination.
Theranos and WeWork are two great examples of companies hated by HN because there's evidence supporting negative opinions.
Edit: here's the thread - not 100% positive but close: https://news.ycombinator.com/item?id=6349349
HN is overly skeptical of startups that take something possible and simplify the UX. Although I can't think of a recent example.
basically someone belittling Dropbox before it went on to be worth billions.
There are always going to be isolated nay-sayers for whatever reasons. When you get a near-consensus on HN that something's a PoS that's something that's worth bearing in mind.