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Audio programming in Nim is completely possible and reasonable.

Here is an example of a super collider plugin written entirely in Nim with the GC turned off: https://forum.nim-lang.org/t/3625

The author seemed to find the experience very pleasant, and the performance was great.

Not (yet) a Nim user, but another post mentioned that GC is thread-specific, so you can remove all traces of GC-types from your real-time thread(s) in order to avoid deallocations at the wrong times.

A related question is whether you can disable GC on a thread by thread basis.

Audio programming? And why is it frowned upon? If it is because of the Java-like GC freezes that is something you can ensure will not happen in Nim by turning on manual control and only running it when its suitable.

Not the person you responded to, but yes. The audio must never be interrupted, everything else first.