I prefer tmux to screen but the default key mappings took some getting used to. I've used it long enough that Ctrl-B and " / % for the screen splitting are natural to me now, but initially it was ... rough.
I have Caps Lock set to be Ctrl and tmux set to use Ctrl+a. For a vertical split, I have it mapped to Ctrl+a, |. For horizontal, Ctrl+a, -
It’s pretty flexible.
# In ~/.tmux.conf Change prefix key to Ctrl+z
unbind C-b
set -g prefix C-zIt is stems 100% from the terminal emulator. Just install a better one. Test your keys with https://metacpan.org/source/PEVANS/Tickit-0.67/examples/demo...
Screenshot: https://i.imgur.com/JfHjJXy.png
The only key combos marked not ok are global/taken by the window manager, so they don't arrive at the application.