My first small business I owned hit every bullet point in my career wants and desires and I burned out pretty hard on it. The constant state of being turned on, dangling the career carrot in front of myself wasn't healthy. I had a bad relationship with my own business.
Even though I enjoyed the work, the compensation was good, and I used my hands creatively, my own expectations weren't matching the reality and I still found myself becoming oddly dissatisfied with the work and becoming overwhelmed by the grind.
I think it's much deeper than just work being meaningful. My wife sits on a phone all day really doing useless work for a large publicly traded company and makes great money and absolutely loves it.
I think it boils down to each their own.