`Bind` with named methods goes a long way to cleaning up nested callbacks. Here's a (quick+dirty; I know I'm missing some `do`'s in there) version of the same code in CoffeeScript:

  _ =
    fileMenu: ->
      mainWindow.menu "File", (e,f) => this.onFile(e,f)

    onFile: (err,file) -> 
      if err then throw err
      file.openMenu (e,m) => this.onOpenMenu(e,m)

    onOpenMenu: (err,menu) ->
      if err then throw err
      menu.item "Open", (e,i) => this.onOpen(e,i)
  
    onOpen: (err,item) ->
      if err then throw err
      mainWindow.getChild type('Window'), (e,d) => this.onDialog(e,d)

    onDialog: (err,dialog) ->
      if err then throw err
      #...

  _.fileMenu()

( `=>` is CoffeeScript for a function bound to the current scope )