I think FRP has a place, and React has been a transformative technology for web, but in that case you generally don't even have to think about the rx primitives at all if you don't want to.
As far as RX as it's penetrated mobile development in the past few years, the result I have seen is that many projects have become unreadable tangles of reactive chains, where the stack trace is no longer useful, because of the unfounded assumption that "more reactive" means better code.
The iOS APIs are certainly showing their age, and there's a lot of warts related to their Objective-C pedigree, but I think they have always had a strength in terms of being fairly agnostic about how they are integrated into your program's structure. I really fear that sense will be lost if third party libraries adopt combine as the dominant interface paradigm.