The Barnes and Noble in Clear Lake, TX (near NASA) had a 30'x8' wall of programming and sysadmin books, and 3x that when you take in general computing, math, and science. I loved it. "Corporate" had them rearrange the store a bit, and the selection is (or looks) a bit smaller now.

Borders in San Antonio has a large selection of said topics, and I'm impressed. The only thing about Borders that bugs me is the lack of sitting areas.

I wonder if their demise would actually be good for a lot of independent booksellers whose customers would avoid B&N.