Scientists Demonstrate Mammalian Regeneration Through a Single Gene Deletion | Hacker News Reader

Scientists Demonstrate Mammalian Regeneration Through a Single Gene Deletion

sciencedaily.com

117 pointsdpurp25 comments

I think an important question to research here is why p21 evolved in mammals. The article says knocking it out doesn't appear to increase cancer rates, which would have been my first and only guess.

Maybe somehow it speeds up the system of evolution by keeping life expectancies shorter, thereby increasing turnover (death and new births)? I have no clue just throwing that out there.

To survive natural selection the gene must give the animal some reproductive advantage. I can understand that promoting longevity beyond the reproductive stage of one's life cycle affords no such benefit. But one still has to account for the fact that the lack of the gene appears to increase the survivability in the reproductive pahse as well. Something more must be going on.

Perhaps not having the ability to regenerate leads to more cautious behaviour, avoiding life threatening situations to a much greater extent? Puzzling...

I don't think the ability to regenerate means that losing a limb doesn't hurt...

> To survive natural selection the gene must give the animal some reproductive advantage.

Most probably, but not necessarily.

A gene can be present without being useful because it is linked to another gene that is itself useful; or it can be a leftover from an earlier moment of evolution where it was useful, and then it ceased to be useful but there was never an evolution pressure strong enough to have it disappear.

In summary, just because a gene is present and active does not mean it's useful today.

Strictly speaking, it must give the _gene_ a reproductive advantage, not necessarily the animal. Often, these two advantages are aligned. But they need not be. This is the case in kin altruism. And this is also, why "promoting longevity beyond the reproductive stage of one's life cycle" affords sometimes very much such benefits. Example: grandparents can help raising their children's children (and their children's children's children ;)). Kin altruism becomes even more apparent in ants (or other social animals). Worker ants or bees are pretty much infertile but they help a lot.

It should be noted that the difference is much more extreme for ants than it can be for mammals due to a genetic quirk where a female ant shares 50% of her genes with her children and 75% with her sisters. (Therefore having more sisters is better than having children.)

Still there are mammals that live eusocial. The naked mole rat comes to mind.

Not necessarily. The mutation could have survived for any number of reasons including genetic drift. As long as it didn't kill the organism right away there wouldn't be significant negative pressure to get rid of it.

Individual organisms don't work for "the system of evolution"'s benefit. They work for themselves.

But mammals do! They are social creatures. A social group that has more efficient food use due to turnover of injured members would be selected for.

Group-selection explanations are rarely correct.

Yet empirically the effect exists.

My guess would be that regeneration is too big a drain on the metabolism. Compared to the animals with that ability, mammals have positively ridiculous energy needs already. It may be that better healing from wounds is not sufficiently useful to make up for the strain that the healing itself entails.

So weight reduction (or the ability to eat more food and stay the same weight) and regeneration - now that does sound good!

That's a simple one, chicks dig scars...

I seem to remember reading a while ago that the immune system in animals with regenerative ability needs to be stronger because the blastoma wound is "open" longer and more prone to infection. For humans today we can mitigate infection pretty well relative to a pretty much any mammal in the wild.

They don't mention regenerating anything specific besides holes in ears. Can these mice regenerate digits? Whole limbs? Internal organs? Spinal column damage?

Google? If you follow the link at the bottom of the article will lead you to the PNAS paper. You'll learn that the mice strain is called MRL[1].

It can regenerate its ears, cartillage[2], cardiac muscle after cold-induced lesions[3] but sadly not after infarction/reperfusion[4] and digits (to some extent, in neonate mice)[5]. There may be more.

[1] http://www.pnas.org/content/107/13/5845.full

[2]http://www.eurekalert.org/pub_releases/2001-08/wi-rit080201....

[3] http://www.pnas.org/content/98/17/9830.full

[4] http://onlinelibrary.wiley.com/doi/10.1111/j.1067-1927.2005....

[5] http://onlinelibrary.wiley.com/doi/10.1111/j.1524-475X.2007....

I expect the full effects are not very dramatic, else it would have been noticed earlier, since MRL are commonly used in experiments.

I find it reassuring that this unknown thing was right on our doorstep, and it makes me wonder what other amazing discoveries are just out of reach (or even within reach...) The world is more complex than we see; all we need do is look (a lot...) - There is more in heaven and earth than is dreamt of in your philosophy, Horatio - Nature's imagination is greater than your imagination

From the article, it seem to not be so much that it enables healing, but that it enables healing without scars. I expect this is crucial in some situations, but it's not clear that it can heal what wouldn't otherwise heal. Certainly, there are cosmetic applications.

It was noticed in the nineties. The genetic substrate was discovered this year.

This story is from Mar. 16, 2010

I wonder what's happened since then? You'd think we'd really jump on this kind of science. I wonder why all this stuff is so slow.

Science takes as long as writing computer programs.

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