TypeScript does not come with a minifier. The code it produces is compatible with the target version of JavaScript (e.g. compile ES6 modules into CommonJS) but unminified.
[1] https://github.com/angular/tsickle
[2] 'gents', in this repo https://github.com/angular/clutz
TS pointedly does not minify output. It does the opposite: try to generate code that a human might have written.
It's very easy to incorporate TS into a Babel or Webpack build pipeline though, so you can use a purpose-built minifier of your choice.
They work with Closure-annotated JS (with JSDoc) though; not sure if it fits your use case.
It's a bit difficult to hook up though, and we haven't had the cycles to make the open source version user friendly, I'm afraid :-(