To give a specific example, let's say you have a classical system with only three particles in the entire universe, and further let's say they are interacting via a conservative force. So, how many things are there in the universe? Is each particle communicating with the others to organize their movements? Then, there would be three things in the universe. Is there a potential field permeating all of space, into which the particles project their influence? That would be four things. Is there a "strand of force" connecting each particle to every other particle? Then, there would be six things.
The debates in the paragraph above were alive and well in Newton's time. However they were philosophical debates, not physical debates, because the three suggestions I proposed (along with the other possibilities I didn't mention) are all mathematically equivalent and would lead to the same motion.