Edit: to be clear, price for me was really the main reason to move away from SF and not to move for example to NYC. If there had been city similarly vibrant and interesting, large city as NYC or SF that is affordable I'd have chosen that in a heart beat over Portland.
I get it, I grew up in a small town and this feels like straight townie-ism to me.
Portland people who hate CA transplants have the same mindset as SF people who hate "techies" who have the same mindset as Red Americans who hate immigrants. There are always some cultural differences people point to (they are raising prices!/taking jobs!/crappy people!/more traffic!) but it is really just a form of territorial pissing that dumps negativity on individuals for societal shifts.
Otherwise ... No one occupies the high moral ground. Every newcomer, no matter how far back, changed forever what was there.
Edit: when I lived in San Diego in the seventies, it was all but impossible to get a permit for a new water hookup, effectively banning new homes and therefore new people. Your wife could start with that.
And the native Americans changed the land when they arrived.
And they were always leaving off the last syllables of words. But mainly property prices.
You say that as if it is not.
I could say a lot more, but am not sure what you'd be interested in.