The sample size is so small, that the results are nearly meaningless.
Literally nobody is claiming the results are solid evidence for anything other than that one small study had an interesting and unexpected result.
And the results aren't "nearly meaningless" - they're an indicator that maybe a larger study should be done. I doubt anybody gets funded for big studies shooting into the dark, so smaller "what if..." studies like this are valuable.
Even without knowing that though, I'm surprised, and so is Horvath himself, that they found a full-on reversal of the clock. I don't think anyone was expecting that. I'm betting we won't see that kind of reversal in a future placebo group, though if we do I'm going to be getting myself some good placebo!