When operating at scale, it becomes necessary to have separate processes/systems for schema changes (DDL) vs row data migrations (DML) anyway.
For example, say you need to populate a new column based on data in other columns, across an entire table. If the table is a billion rows, you can't safely run this as a single DML query. It will take too long to run and be disruptive to applications, given the locking impact; it will cause excessive journaling due to the huge transaction; there can be MVCC old-row-version-history pileups as well.
Typically companies build custom systems that handle this by splitting up DML into many smaller queries. It's then no longer atomic, which means such a system needs knowledge about application-level consistency assumptions.