The only problem I've encountered with nextdns is they went down effectively taking out internet and no one at home knowing how to mitigate it.
Otherwise, a good value prop, provided you turn off their logging feature that captures client-ip among other metadata.
Also, keep in mind that you could run Pi-Hole on a VPS and split-VPN only DNS traffic through it: https://docs.pi-hole.net/guides/vpn/only-dns-via-vpn/ DO charges $5 for 1TB traffic and a decent amt of compute, which ought to be enough for 500 or more (?) devices worth of DNS traffic.