Edit: I forgot to mention the most important piece: When a site says that it won't work without JS, I accept this and close the tab. Unless it's Google Maps.

My browser has built-in URL-based filters.

I browse with JS disabled except for a handful of sites, which I enable for the session whenever I need it.

My browser makes it easy, with a three-key shortcut to toggle it.

This is about the extent of it.

I used to use uBO, which I still think is great, and enough for more Chrome and Firefox users. Many blessings to its maintainer.