I've seen a lot of the ones I watch having sponsors that are only vaguely related, such as a certain mattress manufacturer or a certain shopping cart creation site.
I don't mind the ones that relate, but the unrelated ones are very jarring.
Regardless, I almost never watch a second ad for the same product. I skip through them.
I haven't yet gotten to the point that I'd just skip them automatically, though. That's seems extreme.