Sure, I could import all of corejs and call it a day. Everything would be polyfilled, but then I'd be wasting precious bytes and negatively impacting page load times. Some will even say the concern is no more than bikeshedding. But if you give little thought to bundle optimization, your carelessness will add up, and materially impact TTFB. It's a death by a thousand cuts.
My personal answer is no. Whether it's Stockholm Syndrome or not, you can conquer the complexities of shipping web applications written in modern JavaScript.
Becoming aware of the nuances has made me a stronger developer. Developing a deep understanding of polyfills, bundlers, transpilers, module formats (CJS, SystemJS, UMD, ES Module) and which browsers support which APIs has made led to me being more thoughtful in the code that I write. For people just looking to solve a business problem, without understanding the more tedious parts of JavaScript, it absolutely is too complicated for them. I empathize. But if you want to be a skilled front-end software engineer, it's in your interest to tackle these tools with some zeal.