Most of my JavaScript these days is little interactive things embedded in web pages, and I use raw JavaScript. All the stuff I used jQuery for back in the 1990's is in the language and DOM API now.

They generally have the form:

    document.addEventListener('DOMContentLoaded', function() {
      var m = {
        ...model fields...
        _observers: new Set(),
        notify: function() {
          this._observers.forEach(function(observer) {
            observer();
          }
        }
      };

      var elem1 = document.getElementById('...');
      elem1.addEventListener('...', function() {
        ...update fields on m...
        m.notify();
      });
      m._observers.add(function() {
        ...update elem1 from m...
      });

      m.notify();
    });