I primarily use Flask for my research project. It was quick to pick up and honestly, I like a more barebones style - one of the reasons I use Sublime Text over IDEs. Plus Miguel Grinberg's tutorial is fantastic at getting you on your feet (though I'm still sour over changes compared to his original tutorial, more because its made it difficult to onboard new developers).

However, Pyramid's made some of the coolest shirts. http://pylonsproject.storenvy.com/collections/56570-all-prod...