Will chime in and mention aiohttp[1]. It's lightweight, fun, and the API is very user-friendly for those willing to work on a slightly lower level. I use it to build speedy APIs, and coupled with a good ORM (peewee? [2]) it's pretty dope.

1. https://aiohttp.readthedocs.io/en/stable/

2. http://docs.peewee-orm.com/en/latest/