I did not like working remotely honestly. As an extrovert, I did not like the isolation. However, the major drawback was not being able to steer any of the tech/political discussion because I was remote. I had poor managers/CTO that needed a good smack to the head because they were too scatterbrained, but I was not there to do it. Impossible over Slack.
Now that I am job hunting again, I am wary of remote jobs. Of the three roles I am pursuing now, only one is remote. I have a good feeling about this one since there already is a sizable part of the office that is remote.