evil.com can still claim to be mysite.com and trick users into using their security key there, no?
It would presumably have to trick the user into "registering again" since there is no valid key handle for FIDO2 (not sure about classic U2F), but I doubt that users would notice the difference in flows.
The real win is that this spoof would still not give evil.com a credential scoped to mysite.com, but a user would be none the wiser that they are on a different site than they expect (which can still be problematic depending on the nature of the site).