If we accept the heat death of the universe and the fact nothing can go faster than light everything is bound to disappear. Trying to better Earth based life is useless. Then why bother trying to attain something higher? Just maximize your own pleasure until your conscience disappear. Suicide by psychedelic use is the only "hypersane" response.
Among the many things we've learned from science is that there are real phenomena that we cannot perceive. We use microscopes, telescopes, x-ray machines and other sensors of all kinds which create simulacra of the real phenomena which we can perceive.
Extend the analogy to our brains -- consider that there are literally thoughts we cannot think. Our brains tells us there are no thoughts we can't think, but our brains may be liars. Is there a way for our brains to grasp the literally incomprehensible?