I would argue that Pythons biggest issue is performance, which translates in large applications directly into costs. You will need more machines to scale and you will need more power per operation compared to other programming languages.

see here: https://benchmarksgame-team.pages.debian.net/benchmarksgame/...

I think Python makes sense for prototyping and stuff like Jupyter Notebooks. But once mature and going into production I recommend porting stuff to something faster like Java or even Javascript nowadays.