Also try programmable keyboards or custom keymap layouts, which will allow you to map Return to the caps lock key to balance RSI a bit. I have issues with my right index which I almost completely blame on Diablo 1/2, swapping left + right click helps a lot.
I’ve also tried and wouldn’t recommend: Dvorak (no noticeable difference) Egrodox (extremely hard to learn)
Maaaaybeee tiled window managers, dunno where I stand on that one but it probably doesn’t help a lot ergonomics wise.