My only serious RSI experience was on Laptops, with the task switching combo - Alt+Tab (or Cmd+Tab/Cmd+`) - which was really killing my left palm with severe pain.
Since that time I'm remapping left-Alt/Cmd+Tab to left-Alt/Cmd+Spacebar (Karabiner on Mac, Sharpkeys+Autohotkey on Windows), and I'm constantly amazed how good and productive that combo is. And that it should have been used for computers instead of Alt+Tab from factory.
I'll share the configs gladly ofc if anyone's interested.