A former employer was led by huge Clojure fans, who requested that the backend be Clojure, and highly encouraged me to use ClojureScript and something like Reagent for the front-end, which I recently noticed that they finished after my departure. But the more I think about it, the more I can't think of a single feature of ClojureScript that's inherently better than JavaScript, whereas s-expressions are inherently hostile and also have no real-world benefits. JavaScript has destructuring, closures, a flexible module system, object/array spread, basically every syntactical feature Clojure has, but without the s-expressions.
The commonly touted benefit of s-expressions is homoiconicity (code is data), which lets the developer customize the language via macros without needing to wait on the compiler/interpreter authors. But we have this exact same benefit in JavaScript with compilers like Babel. Maybe it's pushed onto another layer of development, but it's in no way less legitimate or useful. The slight benefit you get by being able to do this transformation at runtime is negated by the inconvenience of s-expressions. (Although at first glance, it seems like we could use a better Babel API that lets us transform our code more conveniently. But I think they're working on that?)
The main other benefit I commonly see from people using Clojure or ClojureScript is live development. I saw technomancy made some blog posts about how he used Fennel (a Lisp that compiles to Lua) to do live-coding stuff in Love2d. I was impressed, until I realized that none of these features were specific to Lisp. So I borrowed the same underlying concept he utilized, and started to make a really cool Love2d live development thing just like he had, but in pure Lua.
Now I have the ability to press Cmd-E in VS Code while editing some Lua file, and if I have any code selected, it'll be sent to the live Lovd2d game that's running, to be eval'd, and if there's no selection, the whole current file will be sent. It's the coolest setup ever, almost identical to the awesome setup I had with CIDER + Clojure + Emacs, but without Emacs or s-expressions.