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I think this blog post by the flask author is pretty relevant http://lucumr.pocoo.org/2010/6/14/opening-the-flask/

I can't really respond to the GAE thing as I don't have experience with it.

I'm not sure how relevant Armin is being there, in all my time doing Django development I've never had to do that much work to extend it. Extensions were always clean, repeatable and reliable.

Even if they weren't, I saved countless more hours by using what Django provides than I spent working around what it doesn't.

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