The best way I can come up with to describe it is this:
Think of your morning drive to work. Your distance from the office is always changing as you accelerate and decelerate along the way. It may even stop changing at various times (when you're parked, at stop signs or red lights). If you were to record your distance over time, it would be a curve that goes down (and up when you go in reverse), and sometimes remains level.
The slope of that curve at a given point, that is the derivative, corresponds to the speed displayed by your speedometer at that particular moment in time.
This is differential calculus in a nutshell: given a curve representing your distance over the entire trip, find the speed at any instant in time. We can then relate this to integral calculus in the following way: given a way to record your speed at every moment in time (speedometer), determine the total distance you travel. If it sounds like two sides of the same coin, well it is! This is the brilliant discovery of the fundamental theorem of calculus.