I think it depends on how predictable the consequences are (it may be brilliant, or at least smart, to act in a way that offers a small possibility of an undesireable consequence in return for a large possibility of a highly desireable one), and on how long the time horizon is (it may be brilliant, or at least smart, to act in a way that offers certain undesireable consequences much later in return for certain desireable consequences for a long time before that). To overstate the objection, all actions eventually result in death, which is presumably undesireable.