Web app: Django+Postgres+Bootstrap locally done with Docker, deployed with Heroku.

With Django you get a lot straight out of the box, including: user management, admin dashboards. For an 1 or 2 person built MVP I wouldn't even bother with a JS frontend, just Django forms & Bootstrap templates and full HTTP/POST forms. It simplifies everything and removes a point of failure.

You can get a solid functional system working very, very quickly. Which you can deploy to Heroku for $0 while you iterate, which can be converted to production ready system for as under $50/month depending on what you need.

Desktop: Python+Qt - but thats old and probably bad advice in 2019.