With reasons ranging from too risky in terms of expected cost/benefit, to you can't learn as quickly, to family obligations won't give you the time or energy required.
I personally think the learning speed one is bunk -- even if your brain slows down a little (debatable), it seems more than made up for by experience in how you learn most efficiently, on top of general life experience.
So lists like this help remind you that you still can, if you're so inclined. For more inspiration in the creative direction (e.g. writing like in this list), see particularly the well-known book The Artist's Way by Julia Cameron. [1]
[1] https://www.amazon.com/Artists-Way-25th-Anniversary/dp/01431...