Because of the touch bar I was motived to switch Esc to Caps Lock (using Karabiner Elements), but I have since switched it over on all my machines (i.e. those without touchbars) because it's so convenient/ergonomic.
I've enjoyed having Ctrl where Caps should be so much, and my right hand missed having a Ctrl key on these small Mac keyboards, so I turned the Enter key into Ctrl as well! (Possible as a Complex Modification in Karabiner: "post left_ctrl when enter_or_return is held", so that tapping Enter is still treated like the Enter key)