" Although nicotine is generally considered to be the main compound responsible for the addictive properties of tobacco, experimental data indicate that nicotine does not exhibit all the characteristics of other abused substances, such as psychostimulants and opiates. [...] Because tobacco smoke contains monoamine oxidase inhibitors (MAOIs) and decreases MAO activity in smokers, we have combined MAOIs with nicotine to determine whether it is possible to obtain a locomotor response to nicotine in C57Bl6 mice. [...] Finally, it was found that, whereas naive rats did not readily self-administer nicotine (10 mug/kg/injection), a robust self-administration of nicotine occurred when animals were pretreated with tranylcypromine (3 mg/kg). Our data suggest that MAOIs contained in tobacco and tobacco smoke act in synergy with nicotine to enhance its rewarding effects. "
Tranylcypromine is an MAOI (https://en.wikipedia.org/wiki/Tranylcypromine)
Does anyone know what a locomotor response is? I did a search but got nothing usefu.
Ciggies contain MAOIs, vapes don't (I believe, and they should never be allowed to, but...). Nicotine is seemingly much less addictive without it. This fits in with my own experience, I used nicotine tablets for smoking reduction as a recreational drug, and as an alternative to coffee to wake me up (it's a light buzz, no more). I don't find it addictive, meaning I don't use it much and it doesn't 'call to me' in the way chewing tobacco did when I tried that.