What: Land a man on the moon and return him safely
When: Before the decade is out
That meant NASA could really focus and throw out everything that wasn't directly on that path.
Reusability - take too long, we'll build each craft from scratch.
Permanent mission - Too complicated, keep the missions very short.
Multi-launch architecture - Nope, too complicated again. Launch it all together.
Crew size? Two on the moon so they could help each other, one in the CM to aid in docking. Want a larger crew? Sorry, no. Three is the minimum so that's what you get.
Complicated re-entry vehicles? Nope. We know we can make ablative work.
What is NASA's manned programme for now? Maybe the Moon. When, who knows? Maybe Mars. What architecture, when, how, for how long? Who knows. Moon orbit? For what, when? who knows.
It's impossible to run a clear programme if you don't know what it's for!