If you know who to talk to, you can go to an illegal, underground restaurant where guest chefs like Michael Minna cook. The are no less than 5 hacker warehouses focused solely on robotics development. Two of the old goth warehouses are still available. Sure, and there are bars/night clubs, hundreds of music venues. The closeness to natural beauty combined with all of this is almost unfair. 45% of the city is public parkland.
That's just San Francisco, not mentioning the rest of the bay area. If you can't find a niche in the bay, you would be happier living somewhere that you can find a niche. Why be unhappy just for money?
Nowhere in the world is even close. Maybe Berlin, but I'm not a big fan of Germany.