On long trips on highways it just kills me that I have to stare at the same image for hours basically, and that a program couldn't do that more safely than me.
And if this happens, the airlines and all their fees and cramping and security and bad customer service can be brutally competed against for any trip under 800 miles, and probably longer.
Even a one hour 500 mile trip in a plane is really 3-4 hours, and you don't get a car at your destination, while driving there is about 5-6 hours. If I could surf that whole time or nap, then I'll drive.
If I can sleep overnight, then 8-10 hour drives become far preferable to flying.
If I have friends along the way to visit, or interesting places to vacation in, two or three day trips are more preferable than 1500-2000 mile flights, especially if you have a family and it is way way way cheaper.
Airlines have been reorienting themselves to shorter hops over the last couple decades. Self driving on highways will decimate that business, and only long haul/overseas will remain.