One of the largest peacetime evacuations (>200,000 people) in North America occurred in 1979 when a train carrying toxic materials derailed in Mississauga, Ontario (about 30km from Toronto) [0]. Yet, even with the benefit of the knowledge of that barely averted disaster, trains were and are still barreling through and in proximity of cities.
[0] https://en.wikipedia.org/wiki/1979_Mississauga_train_derailm...